Preheat oven 400 degrees.
Cook the ground beef until just cooked through and drain off any remaining fat.
Reduce stove heat to medium and add salt, black pepper, garlic powder, onion powder, chili powder, cream cheese and half of the cheddar cheese. Stirring mix to cheese is totally melted.
Combine meat and cheese mixture with cooked penne pasta and transfer to a 9″ x 13″ baking dish.
Sprinkling rest cheddar cheese on top.
Baking casserole for 15 mn. When you’re done,serve and Enjoy !