Set oven temperature to 375°F, or 190°C. Spray or coat a 9×13-inch baking dish with olive oil or cooking spray.
Toss together the ground beef, breadcrumbs, Parmesan cheese, egg, garlic powder, dried oregano, dried basil, salt, and pepper in a large mixing bowl. Thoroughly blend all ingredients.
After the baking dish is ready, shape the beef mixture into meatballs that are approximately 1 to 1.5 inches in diameter.
The meatballs should be cooked through and browned in the preheated oven, which should take around 20 to 25 minutes.
While the meatballs are in the oven, cook the spaghetti until it reaches the al dente texture recommended on the box. Put the pasta back in the saucepan after draining.
After the pasta has cooked, add the marinara sauce and mix until evenly coated.