Mix in a large pot, the cooked pasta with chicken, cream of chicken soup, sour cream, milk, garlic powder, onion powder, and parsley. Season with salt and pepper.

Layer half of the pasta mixture in the baking dish, top with half the cheese, then repeat with the remaining pasta mixture and cheese.

Top with a blend of breadcrumbs and melted butter for a crispy finish.

Bake for 25-30 minutes until bubbly and golden brown.

Rest briefly before serving to let the flavors meld perfectly.

Variations & Tips

Add Veggies: Enhance the nutritional value with mushrooms, peas, or your preferred greens.

Spice It Up: A sprinkle of red pepper flakes can add a delightful heat.

Use Leftovers: Rotisserie chicken is a time-saving alternative that’s just as delicious.

Gluten-Free Option: Substitute with gluten-free penne to accommodate dietary needs.

Freezer-Friendly: Prepare ahead, freeze, then thaw and bake for a convenient meal.

Embrace the warmth and comfort of this Homestyle Chicken Penne Casserole, a dish that not only fills the belly but also feeds the soul. It’s a timeless recipe that serves as a reminder of the joy and connection food can bring, making it an ideal choice for family dinners, potlucks, or whenever the heart yearns for a taste of home.